Industrial Post-Doc - Metabolic Engineering
Phycus Biotechnologies
Toronto, ON, Canada
Posted on Oct 27, 2025
This is a support role to the Senior Metabolic Engineer, supported by Phycus and a paid internship through NSERC or MITACS. We are seeking a highly motivated and uniquely skilled scientist to lead a specific project within one chemical production pipeline. The Scientist will be responsible for improving chemical production yields and will develop dynamic control strategies for chemical production. This position will also require experience with bioprocess optimization and may transition to a full-time role upon project completion. Immediate responsibilities include: 1) Computational design and implementation of metabolic pathways and engineering strategies for target chemical molecules. 2) Translation of these metabolic pathway designs into genetic constructs and new microbial strain designs. 3) Scale-up and optimization of the candidate strains in laboratory fermenters, and optimization of production metrics. 4) Building and managing a team of research associates and technicians for development of new products. 5) Analysis and design of metabolic pathways for the production of a wide variety of molecules across multiple microbes. 6) Analysis of data from phenotype testing and using knowledge of microbial metabolism to design a new set of genetic constructs for the next round of strain engineering. 7) Guide experimental projects to achieve company goals; analyze and present fermentation data; and determine next steps. 8) Participate in process evaluations through the analysis and interpretation of lab and demonstration scale data, technical literature, and process simulations; translate this into equipment and process specifications and recommend further R&D and IP opportunities. 9) Mentor and manage junior level personnel. Qualifications: PhD in Chemical Engineering, Microbial Genetics, Biochemistry or similar; post-doctoral or industry experience preferred; demonstrated experience as a metabolic engineer. Experience with high-throughput molecular biology techniques (e.g., Gibson Assembly, LCR, CRISPR). Experience with fermenter assembly and control; understanding of bioprocess optimization. Familiar with metabolic modeling techniques including Flux Balance Analysis and/or Elementary Mode Analysis and MATLAB. Creativity, problem-solving aptitude, good communication and leadership skills. Deep understanding of cellular physiology and metabolism of E. coli or non-conventional yeast strains, and of processes associated with target molecule production. This position is based in Toronto. Competitive salary and employee stock options.